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Fatty Acid Synthetase of Saccharomyces cerevisiae

Exobiology Division, Ames Research Center, National Aeronautics & Space Administration, Moffett Field, California 94035
Life Sciences Division, Stanford Research Institute, Menlo Park, California 94025

ABSTRACT

A light particle fraction of Saccharomyces cerevisiae, obtained from the crude ribosomal material, and containing the fatty acid synthetase, consisted primarily of 27S and 47S components. This fraction has a protein-ribonucleic acid ratio of about 13. Electron micrographs showed particles ranging in diameter between 100 and 300 A in this material. By use of density gradient analysis, the fatty acid synthetase was found in the 47S component. This component contained particles which were predominantly 300 A in diameter and which were considerably flatter than ribosomes, and it consisted almost entirely of protein.