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Suppression of Radiation Sensitivity and Capsular Polysaccharide Synthesis in Escherichia coli K-12 by Ochre Suppressors

Department of Microbiology and LaRabida-University of Chicago Institute, University of Chicago, Chicago, Illinois 60637

ABSTRACT

A class of suppressors effective on nonsense polarity mutations suppresses several independent mutations in a gene (capR) that controls ultraviolet-radiation sensitivity and capsular polysaccharide synthesis. Since these ochre suppressors function at the level of translation of messenger ribonucleic acid into protein, the results provide evidence that the product of the capR gene is a protein.