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J Bacteriol. 1967 October; 94(4): 1025-1033
Copyright © 1967 American Society for Microbiology. All Rights Reserved.

Studies with Hydroxyurea VII. Hydroxyurea and the Synthesis of Functional Proteins

¹ Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York 10032

ABSTRACT

Hydroxyurea affected neither the synthesis nor the degradation of bacterial messenger-ribonucleic acid. The proteins made by hydroxyurea-treated cells were structurally intact and fully functional. Since the expression of the lethal action of hydroxyurea requires active protein production, the data indicate that treated cells do not die as the result of the synthesis of abnormal proteins.