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Formation of -Hydroxyglutaric Acid by Aspergillus glaucus

^a Research Laboratories, Albert Einstein Medical Center, Philadelphia, Pennsylvania 19141

ABSTRACT

Aspergillus glaucus, cultured on sodium propionate-mineral salts medium, incorporates ¹⁴C-glyoxylate into labeled -hydroxyglutaric acid within 30 sec. Mycelial extracts retain this biosynthetic capacity, which is destroyed by heating. Propionyl-2-¹⁴C-coenzyme A also in incorporated into labeled -hydroxyglutaric acid by these mycelial extracts, but to a more limited extent. ¹⁴CO₂ evolution studies, employing differentially labeled ¹⁴C-propionate, indicate C-1 is oxidized by the mold before C-2, and C-2 before C-3. These findings suggest the involvement of -hydroxyglutaric acid in the catabolism of propionic acid by A. glaucus.

¹ Public Health Service fellow (1 F2 AI-31, 566–01).

² Research Career Development awardee of the National Institutes of Health (5-K3-AI-6928).