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J Bacteriol. 1968 March; 95(3): 1051-1055
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Inhibition of Staphylococcal Enterotoxin B Formation by Cell Wall Blocking Agents and other Compounds

¹ Department of the Army, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

Enterotoxin B formation by Staphylococcus aureus S6 was inhibited by Tween 80, oleic acid, sodium deoxycholate, penicillin, D-cycloserine, or bacitracin. Toxin formation by strain 243 was sensitive to oleic acid, sodium deoxycholate, sodium lauryl sulfate, D-cycloserine, or bacitracin. The effect of D-cycloserine was reversed by D-alanine with strain 243 but not with strain S6. Neither penicillin nor bacitracin inhibited -hemolysin or coagulase activity of strain S6; however, 0.118 µmoles of D-cycloserine per ml increased the -hemolysin titer more than eightfold. Pigmentation of strain 243 was reduced by oleic acid, sodium deoxycholate, or methicillin, and was completely inhibited by D-cycloserine or bacitracin. Glucose was required for the inhibition by spermine of ¹⁴C-valine incorporation into cellular protein of strain S6. These data indicate that the cell surface may contain sites important to the synthesis of enterotoxin B.