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J Bacteriol. 1968 March; 95(3): 919-924
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

In Vivo–produced Anthrax Toxin

¹ Department of the Army, Fort Detrick, Frederick, Maryland 21701

ABSTRACT

Specific anthrax antigens were demonstrated in the blood of animals dying from anthrax. These antigens, which appear in the blood at the time when organisms are first detected and whose concentration continues to increase as the number of organisms increases, do not elicit a strong antibody response. The in vivo-produced toxin differs from the in vitro in killing more rapidly and being more difficult to detect. The in vivo toxin exists as an aggregate whose biological and serological activity depends upon its particular composition or configuration, or both.

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