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J Bacteriol. 1968 March; 95(3): 925-931
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Regulation of Pentitol Metabolism by Aerobacter aerogenes I. Coordinate Control of Ribitol Dehydrogenase and D-Ribulokinase Activities

¹ Department of Microbiology, University of Massachusetts, Amherst, Massachusetts 01002

ABSTRACT

Induction studies on Aerobacter aerogenes strain PRL-R3, using ribitol as the inducer-substrate, indicated that two enzymes of ribitol catabolism, ribitol dehydrogenase and D-ribulokinase, are coordinately induced. The utilization of D-arabinose as a substrate resulted in the induction of ribitol dehydrogenase as well as D-ribulokinase. Mutants which were constitutive for ribitol dehydrogenase were also constitutive for D-ribulokinase. In contrast, D-xylulokinase and D-arabitol dehydrogenase did not appear to be coordinately controlled. Induction studies and examination of D-arabitol dehydrogenase constitutive mutants indicated that the three enzymes of the converging pathways for D-arabitol and D-xylose catabolism are under separate control.