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J Bacteriol. 1968 April; 95(4): 1279-1282
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Genetic Map Position of the Gluconate-6-Phosphate Dehydrogenase Gene in Salmonella typhimurium

^a Johns Hopkins University, Baltimore, Maryland 21218
^b National Institute of Arthritis and Metabolic Diseases, Bethesda, Maryland 20014

ABSTRACT

Gluconate-6-phosphate dehydrogenase (GND) is genetically determined in Salmonella typhimurium by a locus (gnd) mapping between the somatic antigen (rfb) and histidine (his) operons. The enzyme is constitutive. Strains of Salmonella carrying an F' genetic element which contains the gnd⁺ gene have GND activity two to three times that of the wild type. This gene dosage effect was used to determine that the GND reaction is not rate-limiting for the metabolism of glucose by the pentose shunt in S. typhimurium.

¹ Present address: Instytut Biochemii i Biofizyki, Warsaw 12, Poland.