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J Bacteriol. 1968 May; 95(5): 1580-1586
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Passive Cutaneous Anaphylaxis with Antigens from Coxiella burneti

Marius Peacock, J. Munoz, George L. Tallent and Richard A. Ormsbee

National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840

ABSTRACT

Passive cutaneous anaphylaxis (PCA) was produced in guinea pigs sensitized with guinea pig Coxiella burneti phase I–II antiserum and challenged with dimethylsulfoxide- or trichloroacetic acid-soluble extracts from phase I cells. The PCA reaction could not be induced by whole or mechanically disrupted phase I or phase II C. burneti cells or by extracted cells or extracts of phase II cells. The antibody responsible for PCA was in the 7S{gamma}1 (fast {gamma}) globulin. Sensitization of the skin by 7S{gamma}1 antibody could be blocked nonspecifically by 7S{gamma}1 globulin from normal serum or from phase II antiserum. The 7S{gamma}2 (slow {gamma}) globulin antibody inhibited the reaction specifically. Some antiserum pools containing high agglutinin and complement-fixing titers to phase I C. burneti cells failed to initiate the PCA reaction, perhaps due to an imbalanced ratio of {gamma}1 to {gamma}2 specific globulins or to an imbalance in the ratio of specific to nonspecific {gamma}1 globulins. Agglutinins to phase I cells were found in both {gamma}1 and {gamma}2 antibody globulins. Complement-fixing antibodies were found in the {gamma}2 globulin fraction.

J Bacteriol. 1968 May; 95(5): 1580-1586
Copyright © 1968 American Society for Microbiology. All Rights Reserved.





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