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J Bacteriol. 1968 June; 95(6): 2031-2034
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

In Vivo Interaction of Endotoxin with a Plasma Lipoprotein Having Esterase Activity

¹ Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts 01545

ABSTRACT

Circulating endotoxin was specifically precipitated from plasma samples withdrawn from three different animal species subsequent to parenteral injection of the toxin. Lipoprotein-positive staining and esterase activity were demonstrated on the precipitation lines formed in immunodiffusion, thus establishing the in vivo interaction of endotoxin with a plasma lipoprotein having esterase activity. Evidence was given to show that the intensity of this interaction in circulating plasma increased gradually with time. The concordance of this in vivo inter-action with the in vitro degradation and inactivation of endotoxin by plasma esterases is discussed.

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