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J Bacteriol. 1968 June; 95(6): 2177-2181
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Prevention of Staphylococcal Bacteriophage Activity by Antigen A Precipitins in Human Sera

Departments of Medicine, Medical College of Georgia, Augusta, Georgia 30902
² Indiana University School of Medicine, Indianapolis, Indiana 46207

ABSTRACT

Antigen A precipitins in human sera prevented plaque formation and propagation of staphylococcal bacteriophages. Over 20% of total IgG was removed from human sera by absorption with staphylococci containing antigen A. The specific precipitating antibody in rabbit antisera formed lines of idenity with antigen A precipitins in lower dilutions of human sera but formed lines of nonidenity with antigen A precipitins in higher dilutions of the same sera, suggesting both specific and nonspecific antigen A precipitins in human sera. The specific and nonspecific antigen A precipitins in human sera may prevent the in vivo activity of staphylococcal bacteriophages which have been demonstrated previously in animals whose sera do not contain either specific or nonspecific antigen A precipitins.