This Article Full Text (PDF) A correction has been published Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Senterfitt, V. C. Articles by Shands, J. W. Search for Related Content PubMed PubMed Citation Articles by Senterfitt, V. C. Articles by Shands, J. W., Jr.

Next Article 

J Bacteriol. 1968 August; 96(2): 287-292
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Salmonellosis in Mice Infected with Mycobacterium tuberculosis BCG I. Role of Endotoxin in Infection

¹ Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32601

ABSTRACT

In agreement with previous observations, mice dying of salmonellosis were found to have a relatively constant number of Salmonella cells in their carcasses (ca. 5 x 10⁹). This number was not the result of bacterial overgrowth in moribund animals and therefore appears to be related to lethality. Similar numbers of salmonellae were recovered from the carcasses of infected mice which had previously been rendered hyperreactive to endotoxin either by infection with M. tuberculosis BCG or by adrenalectomy. In BCG mice, desensitization to endotoxin did not occur during the infection and, therefore, at death these mice contained a number of bacteria which would be equivalent to 1,000 LD₅₀ of endotoxin. Although the number of bacteria recovered from normal mice is roughly equivalent to a lethal quantity of endotoxin, this is obviously not the case in hyperreactive mice. Therefore, the relationship between lethality and 5 x 10⁹ salmonellae cannot be explained by their endotoxin content. Nevertheless, when hyperreactive BCG mice are challenged parenterally with Salmonella, the endotoxin content of the inoculum may markedly influence the course of the infection.

This article has been cited by other articles:

• Bahador, M., Cross, A. S. (2007). Review: From therapy to experimental model: a hundred years of endotoxin administration to human subjects. Innate Immunity 13: 251-279 [Abstract]  
• Cross, A. S. (2002). Invited review: Endotoxin tolerance -- current concepts in historical perspective. Innate Immunity 8: 83-98