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J Bacteriol. 1968 October; 96(4): 975-980
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Selection of a Mutant of Escherichia coli Which Has High Mutation Rates

¹ Department of Botany, University of Michigan, Ann Arbor, Michigan 48104

ABSTRACT

A mutation which causes high mutation rates in all other loci tested was induced with nitrosoguanidine and was selected through the ability of the progeny of such mutant cells to mutate to streptomycin resistance at a higher rate than the wild-type cells. This mutation (mut-2) and the Treffers' mutation (mutT1) mapped at approximately the same position to the right of leu. Specificity studies showed that the two mutations differ in rates of mutation produced.

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