This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Clausen, C. Articles by Bergman, R. K. Search for Related Content PubMed PubMed Citation Articles by Clausen, C. Articles by Bergman, R. K.

 Previous Article  |  Next Article 

J Bacteriol. 1968 November; 96(5): 1484-1487
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Lymphocytosis and Histamine Sensitization of Mice by Fractions from Bordetella pertussis

Department of Microbiology, University of Montana, Missoula, Montana 59801
Rocky Mountain Laboratory, National Institute of Allergy and Infectious Diseases, Hamilton, Montana 59840

ABSTRACT

Administration of Bordetella pertussis cell extracts induced in mice hypersensitivity to histamine, as well as pronounced leukocytosis and hypoglycemia. The leukocytosis was mainly caused by an increase in the small lymphocytes in the circulating blood, and it was most pronounced 3 to 4 days after injection of B. pertussis extracts. Rabbit antimouse lymphocyte serum produced a decrease in the lymphocyte count in normal mice, as well as in mice treated with B. pertussis extracts. This depression in lymphocytes was observed whether the antilymphocyte serum was given 1 day or 2 days after the administration of B. pertussis extracts. The increased histamine sensitivity and hypoglycemia of mice treated with B. pertussis extract were not affected by treatment with antilymphocyte serum, although a marked lymphopenia was present. These observations indicate that the three phenomena observed in pertussis-treated mice are independent of each other.

¹ U.S. Public Health Predoctoral Fellow (5-Fl-GM-13,752-04), National Institute of General Medical Sciences.