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J Bacteriol. 1968 November; 96(5): 1488-1499
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Genetic Control of the ß-Ketoadipate Pathway in Pseudomonas aeruginosa

^a Department of Bacteriology and Immunology, University of California, Berkeley, California 94720

ABSTRACT

The regulation and genetic control of the ß-ketoadipate pathway in Pseudomonas aeruginosa were investigated. The pattern of enzyme induction is apparently the same as in P. putida. Mutants were obtained for all but 1 of the 11 structural genes; the proximity of these genes on the chromosome was examined by transduction of the mutants with phage F116. If a group of enzymes was induced by the same compounds, the corresponding genes were closely clustered. Surprisingly, some locispecifying enzymes not sharing a common inducer were also clustered. It is suggested that this latter finding may indicate a degree of chromosomal specialization.

¹ Present address: Microbiology Unit, Department of Biochemistry, South Parks Road, Oxford, England.