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J Bacteriol. 1968 November; 96(5): 1540-1545
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Antibody Response to Staphylococcus aureus in Rabbits: Sequence of Immunoglobulin Synthesis and Its Correlation with Passive Protection in Mice

Kosaku Yoshida1 and Richard D. Ekstedt

a Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

ABSTRACT

Antibody in hyperimmune rabbit antisera specific for Staphylococcus aureus teichoic acid was shown to be associated with the IgM fraction. Treatment of such sera with mercaptoethanol destroyed its activity in passive mouse protection tests, whereas absorption with antirabbit IgG had no effect. Antibody response in normal rabbits immunized by a single or by three daily injections of a killed vaccine of S. aureus was followed by a sensitive passive hemagglutination test. Antibody detected during the "primary" response was completely susceptible to reduction with mercaptoethanol. Most of the antibody detected after a secondary antigenic stimulation at 10 weeks was also susceptible to mercaptoethanol. The antibody titers correlated well with mouse protective activity, and this activity of the serum was also shown to be associated with the IgM fraction.

FOOTNOTES

1 Present address: Department of Bacteriology, Nippon Medical School, Tokyo, Japan.

J Bacteriol. 1968 November; 96(5): 1540-1545
Copyright © 1968 American Society for Microbiology. All Rights Reserved.



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