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J Bacteriol. 1968 December; 96(6): 1931-1934
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Effect of Immunosuppressive Agents on Normal Phage-neutralizing Antibody in the Mouse

^a Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455

ABSTRACT

The actions of three immunosuppressive drugs on normal antibody synthesis in the adult mouse were determined. Inbred mice were given daily intraperitoneal injections of actinomycin D, uracil mustard, or cyclophosphamide for extended periods. The sera of treated and untreated mice were assayed for phage-neutralizing activity to monitor the effect of each drug on the amount of circulating normal antibody. Except for an initial decrease in titer of normal anti-phage MSP2 activity, actinomycin D had no significant effect on normal antibody activity. Uracil mustard caused alternating elevation and depression of normal antibody titers. Cyclophosphamide caused a prolonged depression of normal antibody. The response patterns to the three immunosuppressive agents were the same for both induced and normal antibody.

¹ Present address: Department of Microbiology, Medical College of Virginia Commonwealth University, Richmond, Va. 23219.