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J Bacteriol. 1968 December; 96(6): 1940-1946
Copyright © 1968 American Society for Microbiology. All Rights Reserved.

Pyrogenic Responses to Staphylococcal Enterotoxins A and B in Cats¹

^a Department of Pharmacology, The University of Texas Southwestern Medical School at Dallas, Texas 75235

ABSTRACT

Pyrogenic responses, ranging up to 4.8 F, were induced in cats by oral administration of highly purified staphylococcal enterotoxin B in doses from 10 to 100 µg/kg. Fever was a more sensitive indicator of intoxication than was emesis. Highly purified preparations of enterotoxin A, whether administered intravenously (0.01 to 1.0 µg/kg), orally (10 to 25 µg/kg), or into the cerebral ventricles (0.005 to 0.020 µg in 0.20 ml), were also pyrogenic in cats. Tolerance to the pyrogenic activity was produced by repeated intravenous injection of a given dose of enterotoxin A but not by repeated intracerebroventricular injection. Enterotoxin A was more potent than enterotoxin B after intravenous injection in causing both fever and emesis. Cross-tolerance could not be demonstrated between enterotoxin A and enterotoxin B or Salmonella typhosa endotoxin. This lack of cross-tolerance plus the inability of large oral doses (100 to 4,700 µg/kg) of endotoxin to cause fever or emesis indicate that the reported responses were attributable to the specific toxins administered and not to contamination by other pyrogens.

¹ This paper was presented in part at the 52nd Annual Meeting of the Federation of American Societies for Experimental Biology, April 1968. (Federation Proc. 27:707.)

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