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J Bacteriol. 1969 February; 97(2): 518-521
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Accumulation of ¹⁴C-Streptomycin by Streptomycin-sensitive and Streptomycin-resistant Group H Streptococci

¹ Department of Microbiology, Northwestern University Medical School, Chicago, Illinois 60611

ABSTRACT

Three streptomycin-resistant mutants of group H streptococcus, strain Challis, were examined for ability to accumulate ¹⁴C-streptomycin. Although the mutants exhibited different levels of transformation, only the streptomycin-sensitive parent Challis strain accumulated significant amounts of ¹⁴C-streptomycin. It appears that impermeability to streptomycin does not necessarily result in reduction or loss of transformability. The amount of label accumulated by strain Challis was correlated with a loss of viability. In addition, accumulation of label was influenced by the concentration of ¹⁴C-streptomycin, the time of exposure, and the type of medium employed.