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J Bacteriol. 1969 February; 97(2): 743-748
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Effects of Cycloheximide and 5-Fluorouracil on Formation of Low-Molecular-Weight Ribonucleic Acid in Yeast

^a Department of Biological Science, Florida State University, Tallahassee, Florida 32306

ABSTRACT

The effects of cycloheximide and 5-fluorouracil on the formation of low-molecular-weight ribonucleic acid (RNA) in yeast were investigated. Both compounds were found to affect the synthesis of low-molecular-weight RNA of ribosomal origin more than transfer RNA but less than the high-molecular-weight ribosomal RNA. 5-Fluorouracil-containing transfer RNA was separated from normal transfer RNA by chromatography on diethylaminoethyl cellulose at 80 C in the presence of 7 M urea.

¹ Present address: Department of Biochemistry, Queens University, Kingston, Ontario, Canada.

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