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J Bacteriol. 1969 February; 97(2): 893-899
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Pathogenicity of the Trudeau Strain of Mycobacterium sp. 607 for Mice

¹ Research Laboratories, Veterans Administration Hospital, Jefferson Barracks, St. Louis, Missouri 63125
² Departments of Microbiology and Pathology, Saint Louis University School of Medicine, St. Louis, Missouri 63125

ABSTRACT

A study was made of the pathogenic properties of the Trudeau Culture Collection strain (T-67) of Mycobacterium sp. 607 for mice. The organism was highly pathogenic for CF1 mice upon intravenous injection. The animals succumbed soon after intravenous injection of a 14 x 10⁶ viable cellular units. The T-67 strain proliferated in the kidneys of the animals but was unable to reproduce in the lungs, liver, and spleen. Destruction of the organisms in the latter organs commenced 24 hr after injection. Tissue bacterial counts showed that the mycobacteria were similarly destroyed in the kidneys after an interval of from 7 to 9 days after injection of the organisms. Histopathological examination of the tissues indicated that the lethal effects of the organism were due primarily to kidney damage. The liver, lungs, and spleen were similarly involved but to a lesser degree. The unique characteristics of the T-67 strain of Mycobacterium sp. 607 are discussed.