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J Bacteriol. 1969 February; 97(2): 940-943
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Mutations to Spectinomycin Resistance Which Alleviate the Restriction of an Amber Suppressor by Streptomycin Resistance

Cancer Research Institute and Department of Bacteriology, Faculty of Medicine, Kyushu University, Fukuoka, Japan

ABSTRACT

Unlike mutations to streptomycin resistance, which restrict the function of an SU II amber suppressor, mutations to spectinomycin resistance have no restrictive effect. Furthermore, mutations to spectinomycin resistance counteract the restrictive action of streptomycin-resistant mutations when combined in a single strain. The mutations to drug resistance, singly or in combination, do not themselves lead to any detectable suppressor activity. The effects on SU II are interpreted in terms of interactions between ribosomal elements.