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J Bacteriol. 1969 March; 97(3): 1005-1008
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Isolation and Partial Characterization of a Staphylococcal Leukocyte Cytotaxin

^a Bacteriology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California 90007

ABSTRACT

A factor which attracts rabbit polymorphonuclear leukocytes both in vitro and in vivo was isolated from the culture filtrate of a strain of Staphylococcus aureus. The activity of the chemotactic factor was independent of fresh serum and it was nondialyzable. Incubation of the factor with heat-inactivated human serum markedly inhibited its chemotactic property. The factor was heat-labile (80 C, 10 min) in the crude culture filtrate but was heat-stable when partially purified.

¹ Present address: Department of Immunology, The Public Health Research Institute of the City of New York, Inc., New York, N.Y. 10016.