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J Bacteriol. 1969 March; 97(3): 1042-1047
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Ocular Lesions Induced by the Trachoma Agent in Rabbits

Francis I. Proctor Foundation for Research in Ophthalmology, University of California San Francisco Medical Center, San Francisco, California 94122
Virus Diseases, Division of Communicable Diseases, World Health Organization, Geneva, Switzerland

ABSTRACT

Injection of the T'ang strain of trachoma agent into the anterior chamber of the rabbit eye caused corneal opacity, characteristic microscopic lesions of the corneal endothelium, varying degrees of neovascularization of the cornea, and uveitis. These ocular changes were agent-specific. The experimental data showed that the microorganism developed in the ocular tissues. The results of this study suggest the possibility of using the rabbit eye as an experimental model for the study of trachoma.