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J Bacteriol. 1969 July; 99(1): 132-135
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Antigenic Structure of Treponema pallidum, Nichols Strain II. Extraction of a Polysaccharide Antigen with "Strain-specific" Serological Activity

Laboratory of Bacteriology and Serology, National Institute of Public Health, Utrecht, Netherlands
Department of Medical Microbiology and Immunology, University of California School of Medicine, Los Angeles, California 90024

ABSTRACT

An ultracentrifugally homogeneous heat-stable polysaccharide preparation free from serologically reactive rabbit testicular tissue antigen, including cardiolipin, was extracted from the Nichols strain of Treponema pallidum, and found to react by complement-fixation with homologous rabbit sera but not with human syphilitic sera. In addition, the reactive "strain-specific" component was found to be distinct from a second reactive component within the preparation related to an antigen of T. reiteri.