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J Bacteriol. 1969 August; 99(2): 459-462
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Correlation Between Growth Inhibition and the Binding of Various Penicillins and Cephalosporins to Staphylococcus aureus

^a Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111

ABSTRACT

The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.

¹ Present address: Department of Chemistry, Villanova University, Villanova, Pa.