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J Bacteriol. 1969 August; 99(2): 469-471
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Isolation of an Antigen of Neisseria gonorrhoeae Involved in the Human Immune Response to Gonococcal Infection

^a Venereal Disease Research Laboratory, Venereal Disease Branch, State and Community Services Division, National Communicable Disease Center, Atlanta, Georgia 30333

ABSTRACT

Ion-exchange chromatography was used to isolate a fraction from disrupted gonococci which reacts with sera from patients with gonococcal disease in complement-fixation and gel-diffusion tests. This antigenic fraction was shown to be the same as that previously described as having been isolated by gel filtration. The method reported here has the advantage of greater rapidity of isolation together with some improvement in purity.

¹ Present address: Department of Clinical Bacteriology, Regional Hospital, Orebro, Sweden.