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J Bacteriol. 1969 August; 99(2): 510-512
Copyright © 1969 American Society for Microbiology. All Rights Reserved.

Identification of Adenosine-3',5'-Monophosphate as the Bacterial Attractant for Myxamoebae of Dictyostelium discoideum

Hubrecht Laboratory and the University of Utrecht, Utrecht, the Netherlands
Department of Biology, Princeton University, Princeton, New Jersey 08540

ABSTRACT

Adenosine-3',5'-cyclic monophosphate was shown to be the compound found in Escherichia coli responsible for the attraction of the amoebae of the cellular slime mold Dictyostelium discoideum. A number of other nucleotides were tested and the following were active: tubercidin-3',5'-cyclic monophosphate, N⁶-2'-O-dibutyryl-adenosine-3',5'-cyclic monophosphate, 5'-methylene adenosine-3',5'-cyclic monophosphonate, guanosine-3',5'-cyclic monophosphate, uridine-3',5'-cyclic monophosphate, cytidine-3',5'-cyclic monophosphate, inosine-3',5'-cyclic monophosphate, and thymidine-3',5'-cyclic monophosphate. They were less active than adenosine-3',5'-cyclic monophosphate. It is suggested that cyclic adenosine monophosphate secreted by the bacteria is used by the amoebae as a means of sensing and orienting towards food.

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