Files in this Data Supplement:

• Supplemental file 1 - Fig. S1, schematic of the PEC formation and cleavage; cleavage reactions for the control Tnp (EK/LP) and mutants; amount of ES-containing oligonucleotides present in PEC, SEB, and DEB complex reactions
  Zipped EPS document, 1.2MB.
• Supplemental file 2 - Fig. S2, schematic of the strand transfer step; strand transfer reaction with control Tnp (EK/LP) and mutants; EtBr-stained gel; amount of DEST product
  Zipped EPS document, 1.1MB.