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J Bacteriol. 1971 August; 107(2): 578-579
Copyright © 1971 American Society for Microbiology. All Rights Reserved.

Enriched Selection of Dominant Mutations: Histidine Operator Mutations

^a Department of Biochemistry, University of California, Berkeley, California 94720

ABSTRACT

In the course of selection of bacteria with derepressed levels of histidine biosynthetic enzymes, it was found that when mutagen-treated cells were spread on a selective medium without allowing intervening growth to occur, the frequency of operator mutants obtained was dramatically increased. This may be useful as a general enrichment for operator or other dominant mutations.

¹ Present address: Department of Nutritional Sciences, University of California, Berkeley, Calif. 94720.