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J Bacteriol. 1972 December; 112(3): 1169-1176
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Isolation of the rec Mutants in Staphylococcus aureus

Matsuhisa Inoue, Hiroshi Oshima, Toyoji Okubo and Susumu Mitsuhashi

Department of Microbiology, School of Medicine, Gunma University, Maebashi, Japan

ABSTRACT

A histidine auxotroph (his–) of Staphylococcus aureus MS3937 and mutants sensitive to ultraviolet (UV) irradiation were obtained. The UV-sensitive mutants were found also to be sensitive to N-methyl-N'-nitro-N-nitrosoguanidine and mitomycin C, and their sensitivity was accounted for by a defect in deoxyribonucleic acid repair. Transduction of either chromosomal or plasmid markers to UV-sensitive mutants showed that these staphylococcus mutants are of the recA (reckless) type mutants as reported in Escherichia coli and Salmonella typhimurium; therefore the UV-sensitive mutants (uvr–) were renamed recombination-deficient mutants (rec–). The biochemical and genetic properties of these mutants are described, and their usefulness for studies of staphylococcal plasmids is discussed.

J Bacteriol. 1972 December; 112(3): 1169-1176
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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