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J Bacteriol. 1972 December; 112(3): 1177-1183
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Elevated Temperatures on Protein Synthesis in Escherichia coli

David Pattersona,1 and David Gillespieb,2

a Department of Biology, Brandeis University, Waltham, Massachusetts; Section on Intermediary Metabolism, Laboratory of Molecular Aging, Gerontology Research Center, National Institute of Child Health and Human Development, Bethesda, Maryland 20014
Baltimore City Hospitals, Baltimore, Maryland 21224

ABSTRACT

Upon a temperature shift from 30 C to 42 to 44 C, Escherichia coli experiences a transient slowdown in rate of optical density increase, uridine incorporation, and amino acid incorporation. The data show that the primary target for thermal inactivation is a molecule(s) required for the initiation of protein synthesis. The effect on ribonucleic acid synthesis is a secondary effect.

FOOTNOTES

1 Present address: Department of Biophysics, University of Colorado Medical Center, Denver, Colo. 80220.

2 Present address: Litton Bionetics, Incorporated, Bethesda, Md. 20014.

J Bacteriol. 1972 December; 112(3): 1177-1183
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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