This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Silverstone, A. E.
Right arrow Articles by Magasanik, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Silverstone, A. E.
Right arrow Articles by Magasanik, B.

 Previous Article  |  Next Article 

J Bacteriol. 1972 December; 112(3): 1184-1192
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Polycistronic Effects of Catabolite Repression on the lac Operon

Allen E. Silverstone1 and Boris Magasanik

a Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

ABSTRACT

The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both ß-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively. We find that both cistrons are affected coordinately by this form of repression. We also find that a single alteration at the lac promoter region is sufficient to abolish sensitivity to repression of both cistrons. From this, we conclude that there is only one target site for catabolite repression in the lac operon.

FOOTNOTES

1 Presently a post doctoral fellow of the Jane Coffin Childs Memorial Fund for Medical Research at the Department of Biological Sciences, Columbia University, New York, N.Y.

J Bacteriol. 1972 December; 112(3): 1184-1192
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»