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J Bacteriol. 1973 December; 116(3): 1267-1272
Copyright © 1973 American Society for Microbiology. All Rights Reserved.

Production of Volatile Nitrogenous Compounds from the Degradation of Streptomycin by Pseudomonas maltophilia1

John J. Fenton2, Harold H. Harsch3 and Dolph Klein4

a Department of Biochemistry, University of Minnesota, St. Paul, Minnesota 55101

ABSTRACT

Ammonia, methylamine, and pyridine were detected in broth filtrates of a streptomycin-degrading strain of Pseudomonas maltophilia during growth on streptomycin as a sole carbon and nitrogen source. Ammonia and methylamine, quantitatively measured by conversion to chromophores with picryl sulfonic acid, were found to accumulate in broth, whereas pyridine concentration increased in the early stages of streptomycin degradation and then decreased as the degradation of the antibiotic neared completion. Exogenous pyridine was metabolized by washed-cell suspensions. Use of N-streptomycin-methyl-14C showed that the methylamine arose from the N-L-glucosamine-methyl moiety of streptomycin. Methylamine was an end product and was not further metabolized by cells.

FOOTNOTES

2 Present address: Department of Chemistry, Southeastern Massachusetts University, North Dartmouth, Mass. 02747.

3 Present address: Marquette University, Milwaukee, Wis. 53233.

4 Present address: Department of Microbiology, University of Minnesota, Minneapolis, Minn. 55455.

1 Scientific Journal Series no. 8296, Minnesota Agricultural Experiment Station, Minneapolis, Minn. 55101.

J Bacteriol. 1973 December; 116(3): 1267-1272
Copyright © 1973 American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Denton, M., Todd, N. J., Kerr, K. G., Hawkey, P. M., Littlewood, J. M. (1998). Molecular Epidemiology of Stenotrophomonas maltophilia Isolated from Clinical Specimens from Patients with Cystic Fibrosis and Associated Environmental Samples. J. Clin. Microbiol. 36: 1953-1958 [Abstract] [Full Text]  
  • Denton, M., Kerr, K. G. (1998). Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia. Clin. Microbiol. Rev. 11: 57-80 [Abstract] [Full Text]  


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