This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reinscheid, D J
Right arrow Articles by Sahm, H
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reinscheid, D J
Right arrow Articles by Sahm, H

 Previous Article  |  Next Article 

J Bacteriol. 1991 May; 173(10): 3228-3230

research-article

Analysis of a Corynebacterium glutamicum hom gene coding for a feedback-resistant homoserine dehydrogenase.

D J Reinscheid, B J Eikmanns and H Sahm

Institut für Biotechnologie, 1 des Forschungszentrums Jülich GmbH, Federal Republic of Germany.

ABSTRACT

From a Corynebacterium glutamicum mutant possessing a homoserine dehydrogenase resistant to feedback inhibition by L-threonine, the corresponding gene (homFBR) was analyzed and compared with the wild-type hom gene. DNA fragment exchange experiments between both genes showed that a 0.23-kb region close to the 3' terminus of homFBR was responsible for deregulation. Nucleotide sequence analysis revealed a single transition from G to A in homFBR leading to replacement of glycine-378 by glutamate in the mutant homoserine dehydrogenase.

J Bacteriol. 1991 May; 173(10): 3228-3230




This article has been cited by other articles:

  • Simic, P., Willuhn, J., Sahm, H., Eggeling, L. (2002). Identification of glyA (Encoding Serine Hydroxymethyltransferase) and Its Use Together with the Exporter ThrE To Increase L-Threonine Accumulation by Corynebacterium glutamicum. Appl. Environ. Microbiol. 68: 3321-3327 [Abstract] [Full Text]  
  • Radmacher, E., Vaitsikova, A., Burger, U., Krumbach, K., Sahm, H., Eggeling, L. (2002). Linking Central Metabolism with Increased Pathway Flux: L-Valine Accumulation by Corynebacterium glutamicum. Appl. Environ. Microbiol. 68: 2246-2250 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»