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J Bacteriol. 1992 January; 174(2): 486-491

research-article

Molecular genetic analysis of the Escherichia coli phoP locus.

E A Groisman, F Heffron and F Solomon

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110-1093.

ABSTRACT

We have cloned the Escherichia coli phoP gene, a member of the family of environmentally responsive two-component systems, and found its deduced amino acid sequence to be 93% identical to that of the Salmonella typhimurium homolog, which encodes a major virulence regulator necessary for intramacrophage survival and resistance to cationic peptides of phagocytic cells. The phoP gene was mapped to kilobase 1202 on the Kohara map (25-min region) of the E. coli genome (Y. Kohara, K. Akiyama, and K. Isono, Cell 50:495-508, 1987) and found to be transcribed in a counterclockwise direction. Both E. coli and S. typhimurium phoP mutants were more sensitive than their isogenic wild-type strains to the frog-derived antibacterial peptide magainin 2, suggesting a role for PhoP in the response to various stresses in both enteric species.

J Bacteriol. 1992 January; 174(2): 486-491




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