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J Bacteriol. 1992 January; 174(2): 619-622

research-article

Bacteriophage T7 RNA polymerase travels far ahead of ribosomes in vivo.

I Iost, J Guillerez and M Dreyfus

Laboratoire de Génétique Moléculaire (Centre National de la Recherche Scientifique D1302), Ecole Normale Supérieure, Paris, France.

ABSTRACT

We show that in Escherichia coli at 32 degrees C, the T7 RNA polymerase travels over the lacZ gene about eightfold faster than ribosomes travel over the corresponding mRNA. We discuss how the T7 phage might exploit this high rate in its growth optimization strategy and how it obviates the possible drawbacks of uncoupling transcription from translation.

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J Bacteriol. 1992 January; 174(2): 619-622

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