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J Bacteriol. 1992 February; 174(4): 1414-1416

research-article

Isocitrate dehydrogenase kinase/phosphatase: identification of mutations which selectively inhibit phosphatase activity.

Department of Biochemistry, University of Minnesota, Minneapolis 55455-0347.

ABSTRACT

Mutations in aceK, the gene encoding isocitrate dehydrogenase kinase/phosphatase, which selectively inhibit phosphatase activity have been isolated. These mutations yield amino acid substitutions within a 113-residue region of this 578-residue protein. These mutations may define a regulatory domain of this protein.

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