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J. Bacteriol., 06 1995, 3323-3325, Vol 177, No. 11
Copyright © 1995, American Society for Microbiology

The peptide antibiotic microcin 25 is imported through the TonB pathway and the SbmA protein

RA Salomon and RN Farias
Departamento de Bioquimica de la Nutricion, Instituto Superior de Investigaciones Biologicas (Consejo Nacional de Investigaciones Cientificas y Tecnicas-Universidad Nacional de Tucuman, Argentina.

Selection of spontaneous mutants for insensitivity to the peptide antibiotic microcin 25 led to the isolation of five categories of mutants. Phenotypic and mapping studies showed the mutations to be located in the fhuA, exb, tonB, and sbmA genes. The latter encodes a cytoplasmic membrane protein which is also required for the penetration of microcin B17.


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