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J. Bacteriol., Jun 1995, 3616-3618, Vol 177, No. 12
Copyright © 1995, American Society for Microbiology

A gratuitous inducer of cat-86, amicetin, inhibits bacterial peptidyl transferase

Z Gu and PS Lovett
Department of Biological Sciences, University of Maryland Baltimore County, Catonsville 21228, USA.

Expression of the chloramphenicol resistance gene cat-86 is regulated by translation attenuation. Among the three ribosomally targeted antibiotics that can induce the gene, only amicetin has an unknown mode of action. Here we demonstrate that the nucleoside antibiotic amicetin is an inhibitor of bacterial peptidyl transferase. Thus, the three inducers of cat-86, chloramphenicol, erythromycin, and amicetin, interact with the peptidyl transferase region of bacterial ribosomes.

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• Michelinaki, M., Mamos, P., Coutsogeorgopoulos, C., Kalpaxis, D. L. (1997). Aminoacyl and Peptidyl Analogs of Chloramphenicol as Slow-Binding Inhibitors of Ribosomal Peptidyltransferase: A New Approach for Evaluating Their Potency. Mol. Pharmacol. 51: 139-146 [Abstract] [Full Text]