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J. Bacteriol., Dec 1995, 6999-7002, Vol 177, No. 23
Copyright © 1995, American Society for Microbiology

Delineation of AbrB-binding sites on the Bacillus subtilis spo0H, kinB, ftsAZ, and pbpE promoters and use of a derived homology to identify a previously unsuspected binding site in the bsuB1 methylase promote

MA Strauch
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.

DNase I footprinting experiments showed that AbrB binds to the regulatory regions of the spo0H, kinB, ftsAZ, and pbpE genes. A conserved motif was found in these and other AbrB-binding sites. A search for Bacillus subtilis DNA sequences containing this motif led to the prediction that AbrB would bind to the promoter controlling the bsuB1 methylase gene. DNase I footprinting experiments confirmed this prediction.

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