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J. Bacteriol., Mar 1995, 1388-1392, Vol 177, No. 5
Copyright © 1995, American Society for Microbiology

Escherichia coli NusG protein stimulates transcription elongation rates in vivo and in vitro

E Burova, SC Hung, V Sagitov, BL Stitt and ME Gottesman
Institute of Cancer Research, College of Physicians and Surgeons of Columbia University, New York, New York 10032.

The rate of transcription elongation in Escherichia coli was reduced when cells were depleted of NusG. In a purified in vitro system, NusG accelerated the transcription elongation rate. The stimulation of the rate of transcription elongation by NusG appears to result from the suppression of specific transcription pause sites.


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