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J. Bacteriol., Oct 1996, 5790-5792, Vol 178, No. 19
Copyright © 1996, American Society for Microbiology

The nucleoid protein H-NS facilitates chromosome DNA replication in Escherichia coli dnaA mutants

T Katayama, M Takata and K Sekimizu
Department of Microbiology, Kyushu University Faculty of Pharmaceutical Sciences, Fukuoka, Japan. katayama@bisei.phar.kyushu-u.ac.jp

Growth inhibition of the dnaA(Cs) mutant, which overinitiates chromosome replication, was shown to be dependent upon the nucleoid protein H-NS. [3H]thymine incorporation experiments indicated that the absence of H-NS inhibited overreplication by the dnaA(Cs) mutant. In addition, the temperature-sensitive phenotype of a dnaA46 mutant was enhanced by disruption of H-NS. These observations suggest that H-NS directly or indirectly facilitates the initiation of chromosome replication.


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