This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Syvanen, A. C. Articles by Kurland, C. G. Search for Related Content PubMed PubMed Citation Articles by Syvanen, A. C. Articles by Kurland, C. G.

 Previous Article  |  Next Article 

J. Bacteriol., Nov 1996, 6192-6199, Vol 178, No. 21
Copyright © 1996, American Society for Microbiology

A chimeric disposition of the elongation factor genes in Rickettsia prowazekii

AC Syvanen, H Amiri, A Jamal, SG Andersson and CG Kurland
Department of Molecular Biology, Biomedical Center, Uppsala University, Sweden.

An exceptional disposition of the elongation factor genes is observed in Rickettsia prowazekii, in which there is only one tuf gene, which is distant from the lone fus gene. In contrast, the closely related bacterium Agrobacterium tumefaciens has the normal bacterial arrangement of two tuf genes, of which one is tightly linked to the fus gene. Analysis of the flanking sequences of the single tuf gene in R. prowazekii shows that it is preceded by two of the four tRNA genes located in the 5' region of the Escherichia coli tufB gene and that it is followed by rpsJ as well as associated ribosomal protein genes, which in E. coli are located downstream of the tufA gene. The fus gene is located within the str operon and is followed by one tRNA gene as well as by the genes secE and nusG, which are located in the 3' region of tufB in E. coli. This atypical disposition of genes suggests that intrachromosomal recombination between duplicated tuf genes has contributed to the evolution of the unique genomic architecture of R. prowazekii.

This article has been cited by other articles:

• Audia, J. P., Winkler, H. H. (2006). Study of the Five Rickettsia prowazekii Proteins Annotated as ATP/ADP Translocases (Tlc): Only Tlc1 Transports ATP/ADP, While Tlc4 and Tlc5 Transport Other Ribonucleotides.. J. Bacteriol. 188: 6261-6268 [Abstract] [Full Text]  
• Frutos, R., Viari, A., Ferraz, C., Morgat, A., Eychenie, S., Kandassamy, Y., Chantal, I., Bensaid, A., Coissac, E., Vachiery, N., Demaille, J., Martinez, D. (2006). Comparative Genomic Analysis of Three Strains of Ehrlichia ruminantium Reveals an Active Process of Genome Size Plasticity.. J. Bacteriol. 188: 2533-2542 [Abstract] [Full Text]  
• Amiri, H., Davids, W., Andersson, S. G. E. (2003). Birth and Death of Orphan Genes in Rickettsia. Mol Biol Evol 20: 1575-1587 [Abstract] [Full Text]  
• Amiri, H., Alsmark, C. M., Andersson, S. G. E. (2002). Proliferation and Deterioration of Rickettsia Palindromic Elements. Mol Biol Evol 19: 1234-1243 [Abstract] [Full Text]  
• Ke, D., Boissinot, M., Huletsky, A., Picard, F. J., Frenette, J., Ouellette, M., Roy, P. H., Bergeron, M. G. (2000). Evidence for Horizontal Gene Transfer in Evolution of Elongation Factor Tu in Enterococci. J. Bacteriol. 182: 6913-6920 [Abstract] [Full Text]  
• Kurland, C. G., Andersson, S. G. E. (2000). Origin and Evolution of the Mitochondrial Proteome. Microbiol. Mol. Biol. Rev. 64: 786-820 [Abstract] [Full Text]