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J. Bacteriol., Dec 1996, 7010-7013, Vol 178, No. 23
Copyright © 1996, American Society for Microbiology

FlgM is a primary regulator of sigmaD activity, and its absence restores motility to a sinR mutant

K Fredrick and JD Helmann
Section of Microbiology, Cornell University, Ithaca, New York 14853, USA.

We have used mini-Tn1O mutagenesis to identify negative regulators of sigmaD activity. Nine independent insertions were mapped to five genes: flgM, flgK, fliD, fliS, and fliT, suggesting that FlgM export is regulated similarly in Bacillus subtilis and Salmonella typhimurium. We show that a deletion of flgM can restore sigmaD activity to a sinR null mutant of B. subtilis, although fla/che operon expression is affected by neither SinR nor FlgM.


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