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J. Bacteriol., Dec 1996, 7167-7172, Vol 178, No. 24
Copyright © 1996, American Society for Microbiology

FtsA is localized to the septum in an FtsZ-dependent manner

SG Addinall and J Lutkenhaus
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66160, USA.

The localization of the cell division protein FtsA in E. coli was examined. FtsA was found to localize to the septum in a ring pattern as previously shown for FtsZ. The localization of FtsA was completely dependent on the localization of FtsZ. Under a variety of conditions that prevented formation of the Z ring, FtsA was unable to localize. In mutants where FtsZ forms structures in addition to Z rings, the pattern of FtsA duplicated these structures. These results suggest that the Z ring recruits FtsA to the septum.


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