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J. Bacteriol., May 1997, 3365-3367, Vol 179, No. 10
Copyright © 1997, American Society for Microbiology

Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coli

OI Sanders, C Rensing, M Kuroda, B Mitra and BP Rosen
Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

In a search for genes responsible for the accumulation of antimonite in Escherichia coli, TnphoA was used to create a pool of random insertional mutants, from which one antimonite-resistant mutant was isolated. Sequence analysis showed that the TnphoA insertion was located in the glpF gene, coding for the glycerol facilitator GlpF. The mutant was shown to be defective in polyol transport by GlpF. These results suggest that in solution Sb(III) is recognized as a polyol by the glycerol facilitator.


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