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J. Bacteriol., Jul 1997, 4620-4622, Vol 179, No. 14
Copyright © 1997, American Society for Microbiology

H-NS and RpoS regulate emergence of Lac Ara+ mutants of Escherichia coli MCS2

JM Gomez-Gomez, J Blazquez, F Baquero and JL Martinez
Servicio de Microbiologia, Hospital Ramon y Cajal, INSALUD, Madrid, Spain.

Two master growth-phase regulatory proteins, H-NS and sigmaS, are involved in the formation of araB-lacZ fusion clones of Escherichia coli MCS2. The stationary-phase sigma factor RpoS is strictly required for the appearance of such mutants, whereas the histone-like protein H- NS represses their emergence. Our results support the idea that genetic changes leading to adaptive mutation in this model system are regulated by physiological signal transduction networks.


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