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J. Bacteriol., 09 1997, 5448-5457, Vol 179, No. 17
Copyright © 1997, American Society for Microbiology

An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport

BR Belitsky, MC Gustafsson, AL Sonenshein and C Von Wachenfeldt
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.

The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.


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