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 Previous Article

J. Bacteriol., Sep 1997, 5648-5653, Vol 179, No. 17
Copyright © 1997, American Society for Microbiology

Protein expression in response to folate stress in Escherichia coli

EY Huang, AM Mohler and CE Rohlman
Department of Chemistry, Pomona College, Claremont, California 91711, USA.

Interruption of folate metabolism by trimethoprim results in the elevated expression of folate stress proteins in Escherichia coli. E. coli grown in culture medium supplemented with the folate-dependent metabolites glycine, methionine, and the purine nucleoside inosine shows reduced expression of folate stress proteins. The folate stress proteins include the universal stress protein, the ferric uptake regulatory repressor, and possibly, lipoamide dehydrogenase, the L protein component of the glycine cleavage enzyme complex.


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